Effects of genetic mutation or deletion of FAAH gene and of FAAH inhibitors on alcohol-related behaviors
| Subjects | Sex | Model | Effect | Reference |
|---|---|---|---|---|
| FAAH KO | Male, female | 2-Bottle choice (24 h, 12%–20%) | Increase (intake and preference), with sex difference | Basavarajappa et al. (2006) |
| FAAH KO | Male, female | [1] 2-Bottle choice (24 h, 3%–15%); | [1] Increase (intake and preference, with sex difference; | Blednov et al. (2007) |
| [2] CPP | [2] No effect | |||
| FAAH KO mice | Male, female | 2-Bottle choice (24 h, 3%–12%) | Increase (intake and preference by systemic (i.p.) URB597, with sex difference | Blednov et al. (2007) |
| C57Bl/6J mice | Male, female | [1] 1-Bottle (4 h, 15%) in DID for 3 wk; | Decrease (intake and preference) by systemic (i.p.) URB597 in IA and ADE (but not DID) models, with no sex difference | Zhou et al. (2017d) |
| [2] 2-Bottle choice (24 h, every other day, 7.5%–30%) in IA; | ||||
| [3] ADE | ||||
| Marchigian Sardinian alcohol-preferring rats | Male | Operant self-administration (10%, 30 min) | Decrease (intake) by intracentral and basolateral amygdala URB597 | Stopponi et al. (2018) |
| FAAH C385A Knock-in mice | Male | 1-Bottle (4 h, 15%) in DID for 4 days and 2-bottle choice (4 h, 15% vs. water) on day 5 | Increase (intake and preference) | Zhou et al. (2016) |
| Human FAAH C385A SNP | Male, female | 2119 Patients | Association with street drug use and problem drug/alcohol use | Sipe et al. (2002) |
| Human FAAH C385A SNP | Male, female | 1434 European Americans with AD diagnosis | Association with probability and severity of alcohol dependence | Sloan et al. (2018) |
AD, alcohol dependence; KO, knockout; SNP, single-nucleotide polymorphisms; URB597, FAAH inhibitor.