TABLE 3

Predicted biliary and canalicular clearances of atovaquone using rat and human SCH

Predicted clearances are expressed as milliliters per minute per kilogram.

ParametersRat SCHHuman SCH
Predicted biliary clearance (eq. 6)19 ± 152.2 ± 2.4
Predicted biliary clearance (eq. 7)0.04 ± 0.040.003 ± 0.003
Predicted canalicular clearance (eqs. 8 and 9)0.8 ± 0.6ND
  • ND, Not determined.