TABLE 1

Pharmacokinetic parameters of atovaquone following a single intravenous bolus dose of 1 mg/kg in Oatp1a/1b knockout, Oct1/2 knockout. and wild-type FVB mice

Mean ± S.D., n = 4. Liver Kp values were calculated as the ratio of atovaquone liver to blood concentrations at distributional equilibrium (30 hours).

ParametersWild-type FVBOatp1a/1b KnockoutOct1/2 Knockout
AUC(0–30) (μg•h/ml)24 ± 318 ± 129.5 ± 0.4
CLobs [(ml/min)/kg]0.53 ± 0.050.86 ± 0.070.46 ± 0.05
Vss (l/kg)0.7 ± 0.10.7 ± 0.10.50 ± 0.08
Liver Kp0.49 ± 0.060.61 ± 0.110.53 ± 0.06