TABLE 2

Estimated parameters for bortezomib effects on temporal myeloma cell proliferation

Parameter (unit)	Estimate % CV
Parameter (unit)	U266	RPMI8226	MM.1S	NCI-H929
k_g (h⁻¹)	0.0192^{^a}	0.0169^{^a}	0.0214^{^a}	0.0235^{^a}
K_max (h⁻¹)	0.0710 (11)	0.0671 (7.3)	0.170 (30)	0.244 (26)
KC₅₀ (nM)	3.49 (22)	2.62 (14)	5.87 (52)	14.3 (53)
γ	1.32 (23)	1.54 (23)	1.34 (23)	0.966 (14)
R₀	1.00^{^a}	1.00^{^a}	1.00^{^a}	1.00^{^a}
σ₂	0.372 (10)	0.392 (11)	0.0468 (49)	0.367 (11)

↵^a Fixed parameter value.