Comparison of the in vitro signal-to-noise ratio of LSN3172176 binding to recombinant human M1 mAChRs vs. other known PET tracer ligands binding to their target receptors, also expressed in recombinant systems
| Target | Ligand | Membrane | [Ligand] | In Vitro Signal-to-Noise Ratio (S/N) | Human Tissue Bmax |
|---|---|---|---|---|---|
| μg/well | /nM | fmol/mg | |||
| Human M1 | LSN3172176 | 20 | 10 | 21 | 224 (Table 4) |
| Human 5-HT2A | MDL100907 | 20 | 10 | 5 | 136 and 164 ([3H]ketanserin binding; Laruelle et al., 1993) |
| Human CGRP | MK4232 | 20 | 10 | 7 | 33.4 (Hostetler et al., 2013) |