Summary statistics for aspirin pharmacokinetic parameters by treatment time point and acetaminophen (internal control)
Values are represented as median (interquartile range).
| Period 1 (Morphine, 5 mg i.v. Bolus Injection) | Period 2 (Placebo) | ||||||
|---|---|---|---|---|---|---|---|
| ASA | N | Cmax (mg/liter) | tmax (min) | AUC0–∞ (mg•h/liter) | Cmax (mg/liter) | tmax (min) | AUC0–∞ (mg•h/liter) |
| Prior aspirin (−30, −15 min) | 10 | 1.5 (1.1–2.0) | 30 (28–45) | 90 (70–103) | 1.8 (1.4–1.9) | 30 (20–30) | 84 (60–103) |
| Simultaneous with aspirin (−5, 0, +5 min) | 15 | 1.6 (1.4–2.5) | 30 (20–30) | 100 (92–120)** | 1.6 (1.4–2.0) | 30 (20–30) | 79 (67–98) |
| Post aspirin (+15, +30 min) | 10 | 1.8 (1.5–2.1) | 25 (20–30) | 90 (67–123) | 1.9 (1.4–2.3) | 20 (20–30) | 82 (72–92) |
| Pooled (−30, −15, −5, 0, +5, +15, +30 min) | 35 | 1.8 (1.4–2.1) | 30 (20–30) | 98 (73–118)*** | 1.7 (1.4–1.9) | 30 (20–30) | 82 (67–94) |
| Salicylic acid | |||||||
| Prior aspirin (−30, −15 min) | 10 | 6.6 (5.3–8.4) | 90 (60–98) | 1682 (1214–2161) | 7.2 (5.9–8.6) | 90 (56–90) | 1863 (1388–1923) |
| Simultaneous with aspirin (−5, 0, +5 min) | 15 | 6.7 (6.1–9.0) | 60 (60–90) | 1793 (1429–2478) | 7.6 (6.7–8.4) | 60 (60–60) | 1590 (1378–1958) |
| Post aspirin (+15, +30 min) | 10 | 7.0 (6.6–9.0) | 60 (45–90) | 1557 (1373–2451) | 7.1 (6.6–9.1) | 60 (60–90) | 1455 (1397–2553) |
| Pooled (−30, −15, −5, 0, +5, +15, +30 min) | 35 | 6.7 (6.1–8.3) | 60 (60–90) | 1700 (1408–2142)* | 7.3 (6.5–8.4) | 60 (60–90) | 1532 (1395–1923) |
| Acetaminophen | |||||||
| Prior aspirin (−30, −15 min) | 4 | 13 (8–17) | 90 (90–90) | 253 (1790–4252) | 15 (11–18) | 45 (19–83) | 2395 (1379–4020) |
| Simultaneous with aspirin (−5, 0, +5 min) | 6 | 13 (6–14)* | 105 (83–150)* | 2957 (2713–3835) | 17 (14–21) | 45 (30–60) | 3260 (2785–3482) |
| Post aspirin (+15, +30 min) | 4 | 53 (23–285) | 60 (45–90) | 3461 (2853–4353) | 53 (34–83) | 60 (60–90) | 2832 (1831–3975) |
| Pooled (−30, −15, −5, 0, +5, +15, +30 min) | 35 | 13 (9–16)*** | 90 (60–120)** | 3183 (1988–3482) | 18 (14–20) | 45 (30–60) | 3158 (2708–3961) |
AUC, area under the concentration–time curve; Cmax, maximum plasma concentration; tmax, time to maximum plasma concentration.
* P < 0.05; **P < 0.01; ***P < 0.001 vs. placebo.