TABLE 2 

Survival of Rassf1a−/− animals during DSS-induced inflammation

The presence of RIPK2 inhibitors reduced acute intestinal inflammation and enhanced overall survival of the mice.

RIPK2 InhibitorTreatment and GenotypePercentage Survival
No drugDSS-treated Rassf1a−/−7/30 = 22%
1 (MolPort-016-359-762)DSS-treated Rassf1a−/−8/11 = 73%
2 (MolPort-001-746-327)DSS-treated Rassf1a−/−5/9 = 56%
GefitinibDSS-treated Rassf1a−/−7/15 = 47%