TABLE 4

The tissue-to-blood unbound concentration ratio of small-molecule drugs in brain, spinal cord, sciatic nerve, and DRG

DrugsKp,uu,brKp,uu,scKp,uu,snKp,uu,drg
Carbamazepine0.636 ± 0.1170.948 ± 0.1760.655 ± 0.1861.22 ± 0.17
Haloperidol4.68 ± 1.593.10 ± 1.392.34 ± 0.916.42 ± 3.18
Ralfinamide1.67 ± 0.400.871 ± 0.0972.21 ± 0.484.97 ± 1.21
Ranitidine<0.050.063 ± 0.0250.308 ± 0.1021.44 ± 0.35
Atenolol0.034 ± 0.0080.111 ± 0.0300.670 ± 0.1791.41 ± 0.46
Minoxidil0.175 ± 0.0920.228 ± 0.1020.807 ± 0.3281.54 ± 0.33
Dantrolene0.115 ± 0.0320.160 ± 0.0440.383 ± 0.1701.45 ± 0.63
Loperamide0.063 ± 0.0290.170 ± 0.1420.573 ± 0.1761.40 ± 0.37
Mesoridazine0.105 ± 0.0240.146 ± 0.0460.230 ± 0.0760.617 ± 0.176
Imatinib0.032 ± 0.0060.042 ± 0.0130.251 ± 0.0460.715 ± 0.125
Cyclosporine A<0.005<0.0060.218 ± 0.2670.154 ± 0.057