Data summary: comparison of the Kp estimates among different routes of administration, including a single intravenous bolus (3 mg/kg, i.v.; N = 3 to 4 at each time point), an oral dose (30 mg/kg, PO; N = 4 at each time point), or a continuous steady-state intraperitoneal infusion (40 µg/h, i.p.; N = 4 in each genotype)
Data are presented as the mean. Data for the wild-type genotype after administration of a single oral dose were previously reported (Laramy et al., 2017) and are included in this present study to compare with the three other genotypes that lack efflux transporters.
| Genotype | Kpa | DAb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| i.v. | PO | i.p. | i.v. | PO | i.p. | |||||
| A | B | A | B | C | A | B | A | B | C | |
| FVB wild-type | 1.0 | 1.7 | 0.82 | 0.87 | 1.0 | — | — | — | — | — |
| Bcrp1(−/−) | — | — | 1.3 | 1.6 | 1.8 | — | — | 1.6 | 1.9 | 1.7 |
| Mdr1a/b(−/−) | — | — | 3.6 | 4.9 | 3.8 | — | — | 4.4 | 5.7 | 3.7 |
| Mdr1a/b(−/−) | — | — | — | — | — | — | — | — | — | — |
| Bcrp1(−/−) | 10.0 | 11.6 | 14.2 | 12.7 | 15.6 | 9.9 | 6.9 | 17.3 | 14.6 | 15.0 |