| mg/kg | ng | |
A | 10 | | 12 (4 × 3/each) | 15 minutes; 6 hours; 1, 2, 7, and 17 days | 2 hours; 2, 14, and 21 days (n = 3/ea) |
B | | 400 | 16 (4 × 4/each) | 15 minutes; 2 and 6 hours; 3 days | 1 hour; 1, 2, and 5 days |
C | | 400 | 24 (6 × 4/each) | 30 minutes; 1 and 8 hours; 1 and 3 days | 15 minutes; 2 and 6 hours; 1, 2, and 5 days |
D | 3.3 | 50 | 45 (9 × 5/each) | 1, 4, and 8 hours after first IL-23 dose; 1 and 8 hours after the fifth IL-23 dose; 5, 8, and 17 days | 2 and 24 hours after the first IL-23 dose; 0, 2, 4, and 24 hours after the fifth IL-23 dose; 9, 13, and 22 days |
E | 3.3 | 200 | 45 (9 × 5/each) | 1, 4, and 8 hours after first IL-23 dose; 1 and 8 hours after the fifth IL-23 dose; 5, 8, and 17 days | 2 and 24 hours after the first IL-23 dose; 0, 2, 4, and 24 hours after the fifth IL-23 dose; 9, 13, and 22 days |
F | 10 | 200 | 45 (9 × 5/each) | 1, 4, and 8 hours after first IL-23 dose; 1 and 8 hours after the fifth IL-23 dose; 5, 8, and 17 days | 2 and 24 hours after the first IL-23 dose; 0, 2, 4, and 24 hours after the fifth IL-23 dose; 9, 13, and 22 days |
G | 3.3 | 500 | 45 (9 × 5/each) | 1, 4, and 8 hours after first IL-23 dose; 1 and 8 hours after the fifth IL-23 dose; 5, 8, and 17 days | 2 and 24 hours after the first IL-23 dose; 0, 2, 4, and 24 hours after the fifth IL-23 dose; 9, 13, and 22 days |
H | 10 | 200 | 20 (4 × 5/each) | 1 and 24 hours post CNTO 3723 dose on day 0; 0 hours pre- and 24 hours post IL-23 dose on day 2 | 5 and 15 minutes; 1 and 24 hours post IL-23 dose on day 2 |