TABLE 3

Species cross-reactivity of ABBV-615

Species	IL-1β Cross-Reactivity^{^a}		IL-17A Cross-Reactivity^{^a}
Species	Potency (IC₅₀, pM)	Affinity (K_D, pM)	Potency (IC₅₀, pM)	Affinity (K_D, pM)
Human	11 ± 6	6.2 ± 2.1	60 ± 9	≤2
Cynomolgus	7 ± 3	2.6 ± 1.4	163 ± 24	≤8.3
Mouse	11,233 ± 7,105	10,800 ± 809	>50,000	Low binding^{^b}
Rat	>50,000	Low binding^{^b}	12,000 ± 3,237	Low binding^{^b}
Rabbit	1,422 ± 685	ND^{^c}	2,900 ± 1,000	400 ± 98

↵^a Data shown are mean ± S.E. from three independent experiments.
↵^b Poor binding response with very low signal measured in the surface plasmon resonance (BIAcore) assay.
↵^c Not determined due to the lack of purified rabbit IL-1β protein.