TABLE 1

ED₅₀ values in milligrams per kilogram (with 95% CI) obtained in the mouse antinociception assay following 1-hour pretreatment with AM6538

AM6538 Pretreatment	Agonist
AM6538 Pretreatment	THC	WIN 55,212	AM4054
Control	18.2 (11.9, 27.8)	2.8 (1.9, 4.4)	0.38 (0.29, 0.50)
0.1 mg/kg	31.4 (16.1, 61.2)	—^{^a}	—^{^a}
0.3 mg/kg	>300^{^b}	4.0 (2.4, 6.7)	0.56 (0.36, 0.87)
3 mg/kg	>300^b	18.0^{^c} (8.1, 40.4)	2.47^{^c} (1.18, 5.21)

↵^a Not determined.
↵^b Maximum obtained effect <50%, ED₅₀ value not calculated.
↵^c Different from control value (P < 0.05).