TABLE 1

Study design for 13-week cynomolgus monkey toxicology study

Dose Level (mg/kg per Week)	Dose Volume (ml/kg per Week)	Dose Concentration (mg/ml)	Number of Males	Number of Females
0/0 (i.v./s.c.)	2/2^a	0/0	6^{^b}	6^{^b}
20 s.c.	2	10	4	4
65 s.c.	2	32.5	4	4
200 s.c.	2	100	6^{^b}	6^{^b}
200 i.v.	2	100	6^{^b}	6^{^b}

↵^a Animals received vehicle (15 mM histidine, 75 mg/ml sucrose, 0.0163% Tween 80, pH 6.0) both i.v. and s.c., about 5 minutes apart.
↵^b Two animals/sex/group were maintained for a 12-week recovery period.