Myocardial uptake and retention of exogenous metabolites
Number of replicates were as described in the legend to Table 4. Cumulative retention of IDAOL was significantly higher than DNROL retention both in absence and presence of polymorphism (P < 0.001, unpaired Student’s t test). For IDAOL, time at Cmax was 4 hours, and therefore separate determinations of uptake and retention were not assessable (n.a.) (see also legend to Table 4).
| Metabolite | CBR Polymorphism | Uptake μM | Retention μM |
|---|---|---|---|
| DOXOL | − | n.d. | n.d. |
| + | n.d. | n.d. | |
| EPIOL | − | n.d. | n.d. |
| + | n.d | n.d. | |
| DNROL | − | 0.110 ± 0.032 | 0.048 ± 0.010 |
| + | 0.221 ± 0.065 | 0.096 ± 0.018 | |
| IDAOL | |||
| Day 1 | − | n.a. | 0.015 ± 0.004 |
| + | n.a. | 0.029 ± 0.003 | |
| Day 2 | − | n.a. | 0.023 ± 0.004 |
| + | n.a. | 0.035 ± 0.011 | |
| Day 3 | − | n.a. | 0.041 ± 0.013 |
| + | n.a. | 0.081 ± 0.030 | |
| Cumulative | − | n.a. | 0.078 ± 0.010 |
| + | n.a. | 0.160 ± 0.019 |
n.d., Not detectable.