Free brain concentrations of safinamide in rats
Safinamide was administered at 5, 15, and 30 mg/kg (i.p.), and brains were removed 40, 60, and 80 minutes later to match with the veratridine perfusion in microdialysis studies. Safinamide content was analyzed by HPLC-tandem mass spectrometry. Data are mean ± S.D. of three rats per group.
| Time after safinamide (min) | Safinamide free brain concentrations (µM) | ||
|---|---|---|---|
| 5 | 15 | 30 | |
| min | mg/kg | mg/kg | mg/kg |
| 40 | 0.70 ± 0.01 | 1.89 ± 0.76 | 4.77 ± 2.52 |
| 60 | 0.44 ± 0.06 | 1.70 ± 0.73 | 3.04 ± 0.86 |
| 80 | 0.31 ± 0.05 | 1.37 ± 1.14 | 2.71 ± 0.37 |