Agonist | Piglet | Human | |
---|---|---|---|
Right Atrium | Left Atrium | Right Atrium | |
Chronotropic | Inotropic | Inotropic | |
Prucalopride | n = 5 | n = 4 | n = 4 |
Stimulation potency (−log EC50, M) | 7.35 ± 0.25a | 7.17 ± 0.07a | 7.09 ± 0.12 |
Intrinsic activityb | 0.72 ± 0.11a | 0.65 ± 0.05a | 0.51 ± 0.09 |
Blocking potency (−log Kp, M) | 7.09 ± 0.21a | 7.27 ± 0.33 | |
Cisapride | n = 4 | n = 4 | n = 5 |
Stimulation potency (−log EC50, M) | 6.44 ± 0.08c | ND | 6.44 ± 0.14 |
Intrinsic activityb | 0.43 ± 0.06c | 0.09 ± 0.02 | 0.27 ± 0.07 |
Blocking potency (−log Kp, M) | 7.03 ± 0.22 | 6.15 ± 0.31 |
EC50, half maximal effective concentration; Kp, dissociation equilibrium constant; ND, not determined (effects were too small).
↵a Data from Kaumann; personal communication; 12 June 2000, Cambridge, UK.
↵b Intrinsic activity measured with respect to 600 μM 5-HT.
↵c Data previously published (Kaumann et al., 1990).