Pharmacokinetics of INCB040093 in rats following a 5 mg/kg i.v. and a 10 mg/kg PO
| i.v. (5 mg/kg) | |
|---|---|
| Vss (l/kg) | 1.52 ± 0.16 |
| Clearance (l/h per kilogram) | 1.42 ± 0.11 |
| AUC0−∞ (μM × h) | 8.37 ± 0.66 |
| T1/2 (h) | 5.3 ± 0.3 |
| Dose excreted in urine (%) | 0.447 ± 0.29 |
| Renal clearance (l/h per kilogram) | 0.00605 ± 0.0034 |
| PO (10 mg/kg) | |
| Cmax (μM) | 4.82 ± 1.5 |
| Tmax (h) | 0.5 |
| AUC0−∞ (μM × h) | 8.84 ± 1.5 |
| T1/2 (h) | 1.9 ± 1 |
| % F | 53.3 ± 13 |
AUC, area under the curve; T1/2 , half-life; Vss, mean volume of distribution.