TABLE 3

Pharmacokinetics of INCB040093 in rats following a 5 mg/kg i.v. and a 10 mg/kg PO

i.v. (5 mg/kg)
Vss (l/kg)1.52 ± 0.16
Clearance (l/h per kilogram)1.42 ± 0.11
AUC0−∞ (μM × h)8.37 ± 0.66
T1/2 (h)5.3 ± 0.3
Dose excreted in urine (%)0.447 ± 0.29
Renal clearance (l/h per kilogram)0.00605 ± 0.0034
PO (10 mg/kg)
Cmax (μM)4.82 ± 1.5
Tmax (h)0.5
AUC0−∞ (μM × h)8.84 ± 1.5
T1/2 (h)1.9 ± 1
% F53.3 ± 13
  • AUC, area under the curve; T1/2 , half-life; Vss, mean volume of distribution.