TABLE 2

Inhibitory activity of INCB040093 against proliferation of cell lines derived from B cell malignancies

Cell LineMalignancyINCB040093aIdelalisiba
PfeifferDLBCL10 ± 78 ± 6
SU-DHL-6DLBCL15 ± 410 ± 2
WSU-NHLDLBCL21 ± 912 ± 12
SU-DHL-8DLBCL69 ± 15
SU-DHL-5DLBCL71 ± 4388 ± 4
SU-DHL-1DLBCL>3000>3000
SU-DHL-4DLBCL>3000>3000
SU-DHL-10DLBCL>3000
SU-DHL-16DLBCL>3000
Rec-1MCL23 ± 52.6 ± 1.7
MinoMCL109 ± 8213 ± 10
Jeko-1MCL145 ± 13614 ± 8
HS-445HL90 ± 39
U-HO1HL407 ± 309
  • a The data represent IC50 ± S.D. in nanomolar.