Cholinergic adverse effects of BQCA treatment in mice
Cholinergic adverse effects such as loose stool, diarrhea, lacrimation, and salivation were assessed after oral administration of BQCA (30–300 mg/kg) in mice. Results represent the incidence rates of each severe symptom (out of a total of six mice). BQCA, benzyl quinolone carboxylic acid.
| BQCA (mg/kg p.o.) | Gastrointestinal Symptom | Lacrimation | Salivation | |
|---|---|---|---|---|
| Loose or Mucous Stool | Diarrhea | |||
| 30 | 2/6 | 2/6 | 0/6 | 0/6 |
| 100 | 1/6 | 5/6 | 0/6 | 0/6 |
| 300 | 0/6 | 6/6 | 0/6 | 0/6 |