Estimated PK parameters of Doc and Cab
| Parameter | Definition | Estimate (RSE%) | IIV (CV%) |
|---|---|---|---|
| Doc | |||
| CL (l/kg per hour) | CL of central compartment | 3.47 (11) | |
| IC50Cab (μg/l) | The concentration of Cab causing half of maximum impact on Doc CL | 5270 (27) | |
| Vc (l/kg) | Distribution volume of central compartment | 0.977 (32) | |
| Q (l/kg per hour) | CL of distribution between central and peripheral compartment | 3.21 (27) | |
| Vp (l/kg) | Distribution volume of peripheral compartment | 4.5 (15) | |
| Residual error | |||
| σ1 | Proportional error (CV%) | 49.4 (10) | |
| σ2 | Additive error (S.D., μg/l) | ||
| Cab | |||
| ka (h−1) | The absorption rate constant of Cab | 2.83 (22) | |
| CL/F (l/kg per hour) | Apparent CL of Cab | 0.244 (9) | |
| Vc/F (l/kg) | Apparent distribution volume of central compartment | 1.37 (11) | |
| Residual error | |||
| σ1 | Proportional error (CV%) | 34.8 (14) | |
| σ2 | Additive error (S.D., μg/l) | 70.57 (25) | |
IIV: interindividual variability, CV: coefficient of variation.