TRE plasma PK in rats for inhaled C16TR formulated in squalane/DOPC/cholesterol-PEG2000 LNP
Values are the mean (n = 21/dose; three rats per time point; seven time points over 24 hours).
| Parameter | C16TR-LNP (µg/kg) | |||
|---|---|---|---|---|
| 0.6 | 1.8 | 6 | 18 | |
| TRE plasma Cmax (ng/ml) | 0.40 | 1.67 | 3.46 | 10.21 |
| TRE plasma Tmax (h) | 1 | 1 | 1 | 1 |
| TRE plasma AUC0–24 h (ng*h/ml) | 1.89 | 7.35 | 19.61 | 70.38 |