TABLE 1 

Partial list of FDA-approved mitochondrially biogenic agents

DrugApproved to TreatMechanismMB References
AtomoxetineADHDSNRIJesinkey et al. (2014b)
CilostazolClaudicationPDE4 inhibitorChen et al. (2016)
FluoxetineMDD, OCDSSRIda Silva et al. (2015)
FormoterolCOPD, asthmaβ2AR agonistWills et al. (2012)
MetforminType 2 diabetesAMPK activatorKristensen et al. (2013)
MetoprololHypertensionβ1-AR blockerSharma et al. (2008)
RiociguatPulmonary hypertensionsGC stimulatorCameron et al. (2016)
RosiglitazoneType 2 diabetesPPARγ agonistStrum et al. (2007)
SildenafilErectile dysfunctionPDE5 inhibitorWhitaker et al. (2013)
  • ADHD, attention-deficit/hyperactive disorder; AMPK, adenosine monophosphate-activated kinase; AR, adrenergic receptor; COPD, chronic obstructive pulmonary disease; FDA, U.S. Food and Drug Administration; MDD, major depressive disorder; OCD, obsessive-compulsive disorder; PDE, phosphodiesterase; PPAR, peroxisome proliferator–activated receptor; sGC, soluble guanylate cyclase; SNRI, serotonin and norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.