TABLE 1

FMO3 variants identified in a subset of samples of this study (n = 285)

Variant No.	Chromosome Position	Nucleotide Change	Location	Amino Acid Change	rs No.	HW P Value	MAF	FMO3 Function	References
1	171061989	C > T	Intron 2		rs4140653	0.6354	0.037
2	171061990	A > G	Intron 2		rs2064074	0.1809	0.47		Koukouritaki et al. (2005)
3	171072862	G > T	Intron 2		rs28363536	0.3712	0.198
4	171076813	T > G	Intron 3			1	0.002
5	171076935	C > T	Exon 4	S147S	rs1800822	1	0.058		Koukouritaki et al. (2005), Yamazaki and Shimizu (2013)
6	171076952	C > T	Exon 4	P153L	rs72549326	1	0.002	Inactive	Treacy et al. (1998), Yeung et al. (2007)
7	171076966	G > A	Exon 4	E158K	rs2266782	0.1308	0.412	Decreased	Furnes et al. (2003), Koukouritaki et al. (2005), Yeung et al. (2007), Yamazaki and Shimizu (2013)
8	171077038	GTCT > G	Intron 4		rs143661234	1	0.058
9	171077274	G > T	Exon 5		rs75904274	1	0.016
10	171077372	C > G	Intron 5		rs2066534	0.9376	0.209		Koukouritaki et al. (2005)
11	171077393	C > A	Intron 5		rs79952472	1	0.002
12	171079971	G > A	Exon 6	V220V	rs373775407	1	0.002
13	171080080	G > A	Exon 6	V257M	rs1736557	1	0.081	No change	Furnes et al. (2003), Koukouritaki et al. (2005), Yeung et al. (2007), Yamazaki and Shimizu (2013)
14	171083128	GTC > G	Intron 6			1	0.002
15	171083174	C > T	Exon 7	N285N	rs909530	1	0.261		Furnes et al. (2003), Koukouritaki et al. (2005)
16	171083208	G > T	Exon 7			1	0.002
17	171083232	G > T	Exon 7	E305	rs61753344	1	0.002	Inactive	Treacy et al. (1998)
18	171083242	A > G	Exon 7	E308G	rs2266780	0.3712	0.198	Decreased	Koukouritaki et al. (2005), Yeung et al. (2007), Yamazaki and Shimizu (2013)
19	171083537	T > C	Intron 7		rs909531	0.6644	0.209		Koukouritaki et al. (2005)
20	171083540	A > G	Intron 7		rs373403267	1	0.002
21	171086457	C > T	Exon 9	R492W	rs72549334	1	0.002	Inactive	Yeung et al. (2007)