TABLE 3

Summary of binary classification for zebrafish and rat to human subjective effects and scheduling status.

CompoundClassHSESchedulingZF CPPRat CPPRat Self-AdministrationReferences
KetamineAnesthetic11011Horton et al. (2013), Guo et al. (2016)
PhencyclidineAnesthetic11111Marglin et al. (1989), Horton et al. (2013)
ProcaineAnesthetic00011Spyraki et al. (1982), Fischman et al. (1983), Kiyatkin and Stein (1994)
TetracaineAnestheticX01XX
AtomoxetineAntidepressant00000dela Pena et al. (2011), Horton et al. (2013)
BupropionAntidepressant00011Horton et al. (2013), Mori et al. (2013)
CitalopramAntidepressantX00X0Horton et al. (2013)
FluoxetineAntidepressantX001XHorton et al. (2013). Faillace et al. (2015)
ChlorpheniramineAntihistamineX011XSuzuki et al. (1999), Horton et al. (2013)
DiphenhydramineAntihistamine10011Halpert et al. (2003), Horton et al. (2013)
MethohexitalBarbiturateX1201Pain et al. (1996), Horton et al. (2013)
PentobarbitalBarbiturate11211Bossert and Franklin (2003), Horton et al. (2013)
DiazepamBenzodiazepine11001Leri and Franklin (2000), Horton et al. (2013)
RimonabantCannabinoid 1 receptor antagonist0X00XHuestis et al. (2007), Li et al. (2008)
∆9-THCCannabinoid receptor agonist11011Braida et al. (2004), Horton et al. (2013)
WIN-55 212Cannabinoid receptor agonistXX021Chaperon et al. (1998), Fattore et al. (2001)
Retigabine (Ezogabine)K+ channel opener110XXDEA (2011)
MPEPmGluR5 receptor antagonistXX011van der Kam et al. (2009)
Fentanylµ-Opioid receptor agonist11111Miller and Nation (1997), Vitale et al. (2003), Horton et al. (2013)
Morphineµ Opioid receptor agonist11111Zhang et al. (2012), Horton et al. (2013)
Oxycodoneµ-Opioid receptor agonist11111Rutten et al. (2011), Horton et al. (2013)
NaloxoneOpioid receptor antagonist00000Bardo and Neisewander (1986), Braida et al. (2005), Horton et al. (2013)
AmphetamineStimulant11111Spyraki et al. (1982), Horton et al. (2013)
CaffeineStimulant10010Bedingfield et al. (1998), Horton et al. (2013)
CocaineStimulant11111Bedingfield et al. (1998), Horton et al. (2013)
EthanolStimulant10111Morales et al. (2012), Horton et al. (2013)
NicotineStimulant10111Pascual et al. (2009), Horton et al. (2013)
  • 1, positive finding; 2, aversive in CPP; 0, no effect; X, no data available