TABLE 1

Pharmacokinetic parameters of methylprednisolone

ParameterDefinitionEstimate (CV%)
FBioavailability0.214a,b/1.0c
FrFraction absorbed by ka10.73a,b/NAc
ka1 (h−1)Absorption rate constant1.26a,b/NAc
ka2 (h−1)Absorption rate constant0.22a,b/NAc
VP (ml/kg)Plasma volume of distribution718.7a,b,c
VT (ml/kg)Tissue volume of distribution913.5a,b,c
CLD (l/h/kg)Distribution clearance2.6a,b,c
CL (l/h/kg)Clearance4.0a,b/8.3c (10.1)
  • a Intramuscular parameter values fixed from Hazra et al. (2007b).

  • b 50 mg/kg IM bolus.

  • c 0.3 mg/kg/h SC infusion.