Species | Compound | CL | Vss | ||
---|---|---|---|---|---|
Observed | Simulated | Observed | Simulated | ||
ml/min/kg | ml/min/kg | l/kg | l/kg | ||
Rat | ACT-541468 | 85 | 104 | 3.9 | 2.5 |
ACT-605143 | 32 | 51 | 0.8 | 1.7 | |
ACT-658090 | 36 | 50 | 3.2 | 2.5 | |
Dog | ACT-541468 | 9.5 | 15 | 2.4 | 2.9 |
ACT-605143 | 7.4 | 7.7 | 1.1 | 2.4 | |
ACT-658090 | 3.9 | 4.9 | 2.2 | 3.3 | |
Human | Almorexant | 8.9b | 8.1 | 8.5b | 8.9 |
Suvorexant | 0.8c | 1.0 | 0.6c | 0.4 | |
ACT-541468 | 1.0 | 1.2 | 0.4 | 0.5 | |
ACT-605143 | N/A | 0.2 | N/A | 0.2 | |
ACT-658090 | N/A | 0.1 | N/A | 0.2 |