TABLE 1

Inhibition of human and rat MAO-B and MAO-A by different compounds

Data are means ± S.D. of 2–8 independent experiments.

IC50Human Recombinant EnzymeRat Native Enzyme
MAO-B, nMMAO-A, nMRatio A/BMAO-B, nMMAO-A, nMRatio A/B
Sembragiline5.9 ± 0.623852 ± 59765314.7 ± 1.57700 ± 830524
Selegiline5.5 ± 0.261424 ± 692596.1 ± 1.3969 ± 139159
Rasagiline13 ± 0.9680 ± 129524.3 ± 0.1422 ± 998