TABLE 4.

Mean PK parameters (%CV) for CTP-656, d18-ivacaftor, and ivacaftor in male Sprague-Dawley rats (10 mg/kg) and male beagle dogs (3.0 mg/kg) after oral administration

CompoundCmax (ng/ml)AUC0–24 hr (h*ng/ml)C24hr (ng/ml)t1/2 (h)
PK parameters in male Sprague-Dawley rats
 Ivacaftor1913 (7%)22,177 (24%)346 (54%)10.5 (17%)
 CTP-6561970 (15%)24,260 (17%)413 (19%)13.2 (9%)
 d18-Ivacaftor2460 (28%)31,556 (20%)623 (24%)14.8 (9%)
PK parameters in male beagle dogs
 Ivacaftor2255 (33%)29,448 (29%)774 (30%)17.6 (6.9%)
 CTP-6563463 (9%)49,782 (15%)1418 (31%)22.8 (62%)
 d18-Ivacaftor3030 (38%)40,019 (33%)1089 (43%)18.0 (26%)