TABLE 2

Potency of CFTR potentiation in lumacaftor-corrected F508del/F508del HBE cells by ivacaftor and deuterated ivacaftor analogs

CompoundEC50, nM (95% CI)aCompoundEC50, nM (95% CI)a
Ivacaftor387 (275–545)CTP-656295 (151–575)
M1390 (259–588)d8-M1286 (164–500)
M62410 (927–6269)d6-M63048 (undetermined)
  • Current traces of representative data are shown in Supplemental Fig. 16.

  • a Calculated using AUC potentiator Ieq (µA/cm2) after forskolin addition, n = 3.