TABLE 3

Semiquantitive analysis of M1 metabolites versus parent after incubation of ivacaftor, CTP-656, and d18-ivacaftor in human hepatocytes

CompoundParent Area (mAU)M1 Area (mAU)M1 Formed as % of Parent
Ivacaftor3.320.74923
CTP-6563.090.36512
d18-ivacaftor3.280.2989.1