Potency of CFTR potentiation in G551D/F508del HBE cells by ivacaftor and deuterated ivacaftor analogs
| Compound | EC50, nM (95% CI)a | Compound | EC50, nM (95% CI)a |
|---|---|---|---|
| Ivacaftor | 336 (295–382) | CTP-656 | 255 (220–296) |
| M1 | 960 (756–1220) | d8-M1 | 1346 (1040–1743) |
| M6 | 11,320 (8906–14,380) | d6-M6 | 15,140 (10,390–22,050) |
Current traces of representative data are shown in Supplemental Fig. 16.
↵a Calculated using AUC potentiator Ieq (µA/cm2) after forskolin addition, n = 3.