TABLE 2

ED₅₀ values and 95% confidence limits (CLs) for rimonabant, alone and in combination with AM-2201, JWH-122, CP-47,497, and JWH-250, in ∆⁹ -THC–treated (1 mg/kg/12 hours) rhesus monkeys discriminating rimonabant (1 mg/kg i.v.)

Potency ratios and 95% CLs are the ED₅₀ values of rimonabant in combination with the agonist divided by the ED₅₀ value of rimonabant alone.

Drug	ED₅₀ Value (95% CL)	Potency Ratio (95% CL)
Rimonabant (cumulative dosing)	0.25 (0.16––0.39)
+ CP 47,497 (0.32 mg/kg)	0.51 (0.37–0.71)^{^a}	2.0 (1.2–3.6)
+ CP 47,497 (1.0 mg/kg)	1.02 (0.82–1.27)^{^a}	4.1 (2.0–8.5)
+ CP 47,497 (3.2 mg/kg)	2.66 (1.92–3.68)^{^a}	10.6 (2.9–39.3)
Rimonabant (single-bolus dosing)	0.21 (0.12–0.46)
+ AM-2201 (0.1 mg/kg)	0.77 (0.44–1.33)^{^a}	3.7 (1.6–8.3)
+ AM-2201 (0.32 mg/kg)	1.88 (1.67–2.11)^{^a}	9.0 (1.8–42.4)
+ JWH-122 (0.32 mg/kg)	0.49 (0.36–0.67)^{^a}	2.3 (1.3–4.1)
+ JWH-122 (1.0 mg/kg)	1.80 (1.78–1.82)^{^a}	8.6 (1.8–38.8)
+ JWH-250 (1.0 mg/kg)	0.56 (0.54–0.58)^{^a}	2.7 (1.3–5.2)
+ JWH-250 (3.2 mg/kg)	2.21 (1.74–2.82)^{^a}	10.5 (3.4–31.5)

↵^a Significantly different from rimonabant alone.