Channel | 3078379 IWQ IC_{50} (μM) | 3078380 IWQ IC_{50} (μM) |
---|---|---|

hNa_{V}1.1 | >14 (n = 3) | >14 (n =3) |

hNa_{V}1.2 | 2.17 ± 0.07^{a} (n =3) | > 30^{a} (n =3) |

hNa_{V}1.3 | >14 (n =3) | >14 (n =3) |

hNa_{V}1.4 | >14 (n =3) | >14 (n =3) |

hNa_{V}1.5 | >14 (n =3) | >14 (n =3) |

hNa_{V}1.6 | 1.31 ± 0.17 (n =4) | >10 (n =6) |

hNa_{V}1.7 | 0.0032 ± 0.001 (n =5) | 0.391 ± 0.160 (n =6) |

mNa_{V}1.1 | > 30^{a} (n =3) | > 30^{a} (n =3) |

mNa_{V}1.6 | 2.74 ± 0.49^{a} (n =3) | > 30^{a} (n =3) |

mNa_{V}1.7 | 0.0168 ± 0.005 (n =4) | 0.681 ± 0.258 (n =7) |

hNa

_{V}1.1, human Na_{V}1.1; hNa_{V}1.2, human Na_{V}1.2; hNa_{V}1.3, human Na_{V}1.3; hNa_{V}1.4, human Na_{V}1.4; hNa_{V}1.5, human Na_{V}1.5; hNa_{V}1.6, human Na_{V}1.6; hNa_{V}1.7, human Na_{V}1.7; IWQ, IonWorks Quattro; mNa_{V}1.1, mouse Na_{V}1.1; mNa_{V}1.6, mouse Na_{V}1.6; mNa_{V}1.7, mouse Na_{V}1.7.↵

Compound potency determined by manual patch-clamp electrophysiology using the IWQ voltage protocol.^{a}