TABLE 4 

Frequency of diarrhea in mice or rats treated with LX2761

SpeciesLX2761 doseStudy Day
Day 1Day 2Day 3Day 4
mg/kg
Mice1.5a9 of 105 of 103 of 10
0.15c0 of 152 of 150 of 150 of 5
0.1b0 of 50 of 50 of 50 of 5
0.075b0 of 50 of 50 of 50 of 5
0.05b0 of 50 of 50 of 50 of 5
0.015a0 of 100 of 100 of 10
0.0a0 of 100 of 100 of 10
Rats0.25b1 of 51 of 52 of 5
0.125b1 of 51 of 50 of 5
0.0625b0 of 50 of 50 of 5
0.0b0 of 50 of 50 of 5
  • a 8:00 AM dosing

  • b 5:00 PM dosing

  • c 10 dosed at 8:00 AM, 5 dosed at 5:00 PM