Pharmacokinetic parameters after rats received a 1 mg/kg intravenous dose of LX2761 or sotagliflozin
| Compound | N | Half-Life | AUC0–∞ | CL | Vss |
|---|---|---|---|---|---|
| hr | nM*hr | ml/min per kilogram | l/kg | ||
| LX2761 | 4 | 1.2 ± 0.5 | 581 ± 117 | 49.1 ± 10.6 | 2.2 ± 0.3 |
| Sotagliflozin | 4 | 0.9 ± 0.09 | 1847 ± 132 | 21.3 ± 1.5 | 1.4 ± 0.07 |
N, number of animals; CL, clearance; Vss, volume at steady state.