Pharmacokinetic parameters after rats received a 50 mg/kg oral dose of LX2761 or sotagliflozin
| Compound | N | Half-Life | Tmax | Cmax | AUC0–last | AUC0–∞ | %F |
|---|---|---|---|---|---|---|---|
| hr | hr | nM | nM*hr | nM*hr | % | ||
| LX2761 | 5 | N/A | 0.6 ± 0.2 | 37 ± 27 | 424 ± 134 | N/A | <5 |
| Sotagliflozin | 4 | 2.42 ± 0.08 | 1.88 ± 1.55 | 11918 ± 6250 | 52027 ± 6722 | 52103 ± 6712 | 56 ± 7 |
N, number of animals; %F, % bioavailable; N/A, value could not be calculated owing to low exposure.