TABLE 1 

LX2761 inhibits SGLT-mediated glucose transport

SpeciesSGLT1SGLT2
IC50NIC50N
nMnM
Humana2.2 ± 0.772.7 ± 0.86
Mouse3.7 ± 0.961.0 ± 0.36
Rat5.7 ± 1.431.1 ± 0.43
Dog5.1 ± 0.771.8 ± 0.610
Monkey1.4 ± 0.281.1 ± 0.28
  • IC50, concentration causing half-maximal inhibition; N, number of determinations.

  • a Data are from Goodwin et al., 2017.