AHN 1-055 pretreatments (i.p.) |
R(+)-SKF 81297 self-administration | F4,60 = 12.1; P < 0.001 | F3,60 = 5.17; P = 0.012 | F12,60 = 3.70; P < 0.001 | 3.2 mg/kg (i.p.) at EXT, t = 4.15, P < 0.001 (Δ = +0.109) |
3.2 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 4.47,
P < 0.001 (Δ = +0.118) |
(±)-SKF 82958 self-administration | F4,60 = 12.0; P < 0.001 | F3,60 = 3.44; P = 0.044 | F12,60 = 3.27; P = 0.001 | 3.2 mg/kg (i.p.) at EXT, t = 3.54, P = 0.002 (Δ = +0.156) |
3.2 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 4.20,
P < 0.001 (Δ = +0.185) |
R(–)-NPA self-administration | F4,60 = 6.60; P = 0.001 | F3,60 = 9.48; P < 0.001 | F12,60 = 8.33; P < 0.001 | 3.2 mg/kg (i.p.) at EXT, t = 6.18, P < 0.001 (Δ = +0.101) |
3.2 mg/kg (i.p.) at 0.10 µg/kg per inj (i.v.), t = 5.97,
P < 0.001 (Δ = +0.097) |
(–)-Quinpirole self-administration | F4,60 = 3.64; P = 0.022 | F3,60 = 5.48; P = 0.010 | F12,60 = 4.80; P < 0.001 | 3.2 mg/kg (i.p.) at EXT, t = 4.61, P < 0.001 (Δ = +0.169) |
3.2 mg/kg (i.p.) at 3.2 µg/kg per inj (i.v.), t = 4.35,
P < 0.001 (Δ = +0.159) |
10 mg/kg (i.p.) at 32 µg/kg per inj (i.v.), t = 3.41,
P = 0.003 (Δ = −0.125) |
Remifentanil self-administration | F4,60 = 6.87; P = 0.001 | F3,60 = 1.59; P = 0.234 | F12,60 = 3.81; P < 0.001 | 3.2 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.) t = 3.18,
P = 0.007 (Δ = −0.096) |
3.2 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 4.28,
P < 0.001 (Δ = −0.129) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.68,
P = 0.002 (Δ = −0.111) |
AHN 2-005 pretreatments (i.p.) |
R(+)-SKF 81297 self-administration | F4,60 = 13.3; P < 0.001 | F3,60 = 2.28; P = 0.121 | F12,60 = 4.08; P < 0.001 | 1.0 mg/kg (i.p.) at 3.2 µg/kg per inj (i.v.), t = 4.87,
P < 0.001 (Δ = +0.045) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.94,
P = 0.001 (Δ = −0.037) |
(±)-SKF 82958 self-administration | F4,60 = 12.7; P < 0.001 | F3,60 = 2.38; P = 0.110 | F12,60 = 3.84; P < 0.001 | 1.0 mg/kg (i.p.) at 3.2 µg/kg per inj (i.v.), t = 3.41,
P = 0.003 (Δ = −0.024) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.97,
P = 0.001 (Δ = −0.028) |
R(–)-NPA self-administration | F4,60 = 6.82; P = 0.001 | F3,60 = 4.85; P = 0.015 | F12,60 = 5.74; P < 0.001 | 1.0 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 5.85,
P < 0.001 (Δ = −0.029) |
3.2 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 5.61,
P < 0.001 (Δ = +0.028) |
(–)-Quinpirole self-administration | F4,60 = 3.81; P = 0.018 | F3,60 = 3.19; P = 0.054 | F12,60 = 2.65; P = 0.007 | 1.0 mg/kg (i.p.) at 32 µg/kg per inj (i.v.), t = 4.57,
P < 0.001 (Δ = −0.101) |
3.2 mg/kg (i.p.) at 32 µg/kg per inj (i.v.), t = 2.74,
P = 0.023 (Δ = −0.061) |
Remifentanil self-administration | F4,60 = 6.78; P = 0.001 | F3,60 = 3.17; P = 0.055 | F12,60 = 2.92; P = 0.003 | 1.0 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 3.05,
P = 0.011 (Δ = −0.077) |
1.0 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.19,
P = 0.007 (Δ = −0.081) |
3.2 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 2.97,
P = 0.013 (Δ = −0.076) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 5.28,
P < 0.001 (Δ = −0.134) |
JHW 007 pretreatments (i.p.) |
R(+)-SKF 81297 self-administration | F4,60 = 13.5; P < 0.001 | F3,60 = 8.89; P = 0.001 | F12,60 = 6.88; P < 0.001 | 3.2 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 4.79,
P < 0.001 (Δ = +0.049) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.04,
P = 0.020 (Δ = −0.031) |
10 mg/kg (i.p.) at 3.2 µg/kg per inj (i.v.), t = 4.81,
P < 0.001 (Δ = −0.049) |
(±)-SKF 82958 self-administration | F4,60 = 12.4; P < 0.001 | F3,60 = 6.83; P = 0.004 | F12,60 = 4.98; P < 0.001 | 1.0 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 4.99,
P < 0.001 (Δ = +0.036) |
10 mg/kg (i.p.) at 3.2 µg/kg per inj (i.v.), t = 4.94,
P < 0.001 (Δ = −0.036) |
R(–)-NPA self-administration | F4,60 = 7.51; P < 0.001 | F3,60 = 3.70; P = 0.036 | F12,60 = 4.56; P < 0.001 | 1.0 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 2.83,
P = 0.036 (Δ = −0.015) |
3.2 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 4.37,
P < 0.001 = −0.023) |
10 mg/kg (i.p.) at 0.32 µg/kg per inj (i.v.), t = 3.35,
P = 0.008 (Δ = −0.018) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 4.38,
P < 0.001 (Δ = −0.023) |
(–)-Quinpirole self-administration | F4,60 = 3.51; P = 0.025 | F3,60 = 2.11; P = 0.142 | F12,60 = 1.72; P = 0.086 | |
Remifentanil self-administration | F4,60 = 7.08; P = 0.001 | F3,60 = 2.42; P = 0.106 | F12,60 = 1.95; P = 0.046 | 1.0 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.48,
P = 0.006 (Δ = −0.098) |
3.2 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 4.22,
P < 0.001 (Δ = −0.119) |
10 mg/kg (i.p.) at 1.0 µg/kg per inj (i.v.), t = 3.55,
P = 0.005 (Δ = −0.100) |