Fractional Excretion (%) | Vehicle | Bosentan | Sitaxentan |
---|---|---|---|
Sodium | −0.04 ± 0.05 | −0.2 ± 0.2 | 0.1 ± 0.1 |
Potassium | −0.95 ± 1.10 | −0.13 ± 1.9 | −7.6 ± 2.4*,+ |
Chloride | −0.15 ± 0.04 | −0.2 ± 0.1 | 0.4 ± 0.1**,++ |
Creatinine clearance (ml/min) | 0.07 ± 0.16 | −0.02 ± 0.2 | 0.6 ± 0.4 |
↵* P < 0.05; **P < 0.01 versus vehicle; +P < 0.05; ++P < 0.01 versus bosentan.