TABLE 3

IC50 values for the inhibition of B cell activation in primary mouse splenocytes and cytotoxic effects in DOHH-2 lymphoma and HEL 92.1.7 cells

Primary B Cell Activation (CD69)DOHH-2 Cell ViabilityHEL 92.1.7 Cell Viability
nMnMnM
Ibrutinib6.923>10,000
Idelalisib5.4860>10,000
Combo1.18.4>10,000
MDVN100325.21340>10,000