TABLE 4

Pharmacokinetic parameters of MDVN1003 across species

IntravenousOral
Mouse (2 mg/kg)Rat (2 mg/kg)Dog (1 mg/kg)Mouse (10 mg/kg)Rat (5 mg/kg)Dog (3 mg/kg)
Cmax (µM)5.57 ± 1.663.53 ± 0.0373.34 ± 0.24411.3 ± 1.291.27 ± 0.6863.32 ± 1.42
AUClast (µM*h)7.63 ± 0.590.968 ± 0.01222.04 ± 0.57115.2 ± 1.870.751 ± 0.2743.77 ± 1.66
Terminal t1/2 (h)7.16 (N = 2)0.285 ± 0.1490.62 ± 0.271.261.17 ± 0.4641.48 ± 1.26
CL (l/h/kg)0.594 ± NA4.94 ± 0.0651.23 ± 0.327
Vd (l/kg)3.445 ± NA2.02 ± 1.0441.02 ± 0.153
tmax (h)0.250.250.417 ± 0.144
Bioavailability (%)39.8 ± 4.7131 ± 11.361.7 ± 32.1
  • AUClast, area under the plasma concentration-time curve up to the last nonzero concentration; CL, systemic clearance; NA, Not Applicable.