TABLE 2

IC50 values for compounds against BTK and PI3Kδ kinase family members

IdelalisibIbrutinibMDVN1003
nMnMnM
PI3Kα354>100,000275
PI3Kβ90.2>100,000708
PI3Kγ30>1000107
BMX/ETK>100,000<0.144.5
ITK>100,00019.3>300
TEC>100,000<0.1211
  • BMX/ETK, epithelial and endothelial tyrosine kinase; ITK, interleukin-2–inducible T-cell kinase dimethyl sulfoxide; TEC, Tec protein tyrosine kinase.