TABLE 1

Toxicology tissue changes and NIR imaging probes

Toxicology/Tissue	Biologic Tissue Response	Potential Imaging Probe
General markers	Inflammation	MMPSense 680 and 750 FAST^{^a}
		ProSense 680, 750EX, and 750 FAST
		Neutrophil Elastase 680 FAST
	Apoptosis/necrosis	Annexin-Vivo 750^{^a}
	Vascular changes	AngioSense 680EX and 750EX^{^a}
Liver specific	Metabolism	Transferrin-Vivo 750^{^a}
Kidney specific	Glomerular filtration	GFR-Vivo 680^{^a}
	Renin-angiotensin system	ReninSense 680 FAST
Stomach specific	Gastric emptying	GastroSense 680^{^a}
Soft tissue calcification	Calcium deposition	OsteoSense 680 and 750^{^a}
	Cathepsin K activity	Cat K 680 FAST^{^a}

↵^a Probes that are commercially available with some validation data for use in preclinical drug-induced tissue injury applications (Peterson, 2016).