Mean plasma pharmacokinetics of LY3020371 following single oral doses of diester prodrug LY3027788.HCl in male CD-1 mice
| LY3027788.HCl Dose (by Mouth) | LY3020371 Equivalent Dose (by Mouth) | LY3020371 Mean Plasma Pharmacokinetic Parameter | |||
|---|---|---|---|---|---|
| Cmax | Tmax | AUC0–24 | T1/2 | ||
| mg/kg | mg/kg | nM | hour | nM/h | hour |
| 4.8 | 2.7 | 1990 | 0.25 | 2830 | 1.6 |
| 16 | 9.1 | 10,800 | 0.25 | 10,900 | 1.3 |
| 27 | 15.4 | 15,500 | 0.25 | 17,100 | 1.8 |