TABLE 4

Simulated digoxin CLR and AUC0-∞ parameters in different virtual populations

Each value represents the mean of 100 simulated individuals taken from the virtual population provided with the SimCYP simulator after a single 0.75 mg i.v. dose.

PopulationSimulated CLR% of healthy CLRSimulated AUC0-∞% of healthy AUC0-∞
ml/minµg.min/ml
Healthy131.91003.36100
Elderly90.7695.12152
Moderate renal impairment65.9505.68169
Severe renal impairment43.8337.00208