Potency of CL316,243, tolterodine, oxybutynin, and darifenacin in inhibiting EFS-induced contraction of rat bladder strips and combination index of each antimuscarinic with CL316,243
| Drug | IC25 | Upper 95% CI | Lower 95% CI | Combination Index with CL316,243 |
|---|---|---|---|---|
| nM | ||||
| CL316,243 | 2.86 | 5.91 | 1.18 | — |
| Tolterodine | 4.71 | 11.68 | 1.89 | 0.21 |
| Oxybutynin | 22.28 | 68.45 | 8.86 | 0.50 |
| Darifenacin | 5.84 | 11.29 | 3.07 | 0.71 |