TABLE 1

Glycogen clearance comparison by muscle type between Reveglucosidase alfa and rhGAA in Pompe mice

Muscle Type	rhGAA EC₅₀^{^a}	Reveglucosidase Alfa EC₅₀^a	EC₅₀ Ratio^{^b}  (rhGAA/Reveglucosidase Alfa)
	mg/kg	mg/kg
Heart	13.2 (0.893)	5.00 (0.298)	2.85
Diaphragm	32.2 (4.64)	12.1 (1.96)	2.88
Quadriceps	25.2 (4.59)	9.70 (1.12)	2.81
Psoas	54.6 (10.7)	12.4 (2.82)	4.77
Soleus	27.8 (3.47)	9.36 (1.48)	3.22

↵^a Mean (SE).
↵^b To account for differences in molecular weight, a correction factor of 1.0825 was used to convert rhGAA doses in mg/kg to equivalent doses of Reveglucosidase alfa in mg/kg for EC50 ratio comparison (molecular weight: rhGAA = 109 kDA, Reveglucosidase alfa = 118 kDA).