TABLE 4

Physiologic parameters of FRGN, mFRGN, and hFRGN mice (n = 4–9)

	FRGN	mFRGN	hFRGN
Body weight (g)	32.1 ± 3.6	33.0 ± 7.6	30.6 ± 4.0
Liver (% body weight)	7.61 ± 0.27	4.95 ± 0.14^†	10.6 ± 0.31^*
Brain (% body weight)	1.55 ± 0.07	1.27 ± 0.06^†	1.56 ± 0.11
Kidney (% body weight)	2.08 ± 0.18	1.82 ± 0.14	2.24 ± 0.16
Plasma ALT (IU/ml)	113 ± 15.5	52.2 ± 17.0^†	215 ± 30.1*
Plasma cholesterol (mg/dl)	151 ± 11.8	161 ± 11.0	152 ± 15.6
Liver cholesterol (mg/g)	2.17 ± 0.22	2.63 ± 0.20	3.14 ± 0.21^*
Liver triglyceride (mg/g)	1.81 ± 0.62	7.36 ± 1.57^†	3.31 ± 1.05
Total biliary bilirubin in bile (mg/dl)	5.0 ± 0.8	NM	11.6 ± 4.7
Conjugated bilirubin in bile (mg/dl)	1.0 ± 0.2	NM	4.9 ± 1.8^*

NM, not measured.
↵^† Denotes P < 0.05 compared between mFRGN and FRGN mice using two-tailed Student’s t test.
↵* Denotes P < 0.05 compared between hFRGN and FRGN mice using two-tailed Student’s t test.