TABLE 1

Relative activity (RA) (Ehlert, 2008) for potentiator mode versus agonist mode for DETQ

Relative potency is potentiator mode RA divided by agonist mode RA.

ModeEC50 (nM)Top (%)RARelative Potency
Potentiator5.8395.216.3342.8
Agonist30.411.60.38