TABLE 2

Affinity of DETQ for potentiating the D1-mediated cAMP response in various species

Receptors were transiently transfected into HEK293 cells. Values are from nonlinear curve-fitting to a logistic curve. Data points were pooled from experiments carried out on two separate days (n = 8 for all data points).

SpeciesEC50 (nM)SETop (%)S.E.
Human11.41.675.61.8
Dog8.61.385.22.0
Rhesus12.01.680.01.9
Mouse312.047.450.02.6